Research activities

 

Studies Based on Small Molecular Systems

1. Conjugates of calixarenes & carbohydrates possessing variety of binding cores: Organic Synthesis; Coordination & Structural aspects; Structural & Functional Biomimetics for metalloproteins & metalloenzymes (Similar studies with hemi-calixarene like systems)
2. Metal Ion & Molecular Recognition Properties of the Conjugates of Calixarenes & Carbohydrates : As SENSORS
3. Absorption, emission and mass spectrometric studies; Steady state and time resolved fluorescence spectroscopy
4. Computational Evaluation of the structure and energetics of the species of recognition by the SENSOR molecule
5. Nanostructural features of the simple receptors and their species of recognition by Atomic Force Microscopy (AFM), Transmission Electron Microscopy (TEM) & Scanning Electron Microscopy (SEM)
6. Molecular aggregation by Dynamic Light Scattering (DLS) methods

Studies based on proteins, enzymes and nucleic acid

1. Lectin & Glycosidases: Isolation and purification
2. Binding & property modification of lectins by glyco-conjugates: Biochemical and Biophysical Aspects & Nano-structural studies
3. Binding & Inhibition of glycosidases by the conjugates of carbohydrates and calixarenes: Assay, Fluorescence, CD & ITC & Microscopy (AFM, SEM & TEM)
4. Metal ion complexes as Artificial Chemical Nucleases (DNA Cleavage studies)
5. Metal ion up-take by apo-proteins
6. Lectin glycobiology: Biological aspects of lectins and their conjugates
7. Computational docking studies of the conjugates of carbohydrates & calixarenes with lectins and glycosidases

Molecular Dynamics Simulations

1. Building artificial metalloenzymes : With specific reference to Zinc Enzymes
2. Multi-ligand docking : To simulate the real-time binding of small molecules with biomolecules.

Area of Focus:-

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