Glycochemistry Research Lab

Department of Chemistry
Indian Institute of Technology Bombay
Powai, Mumbai 400076

Phone : 022-2576 7166
Fax      : 022 -2576 7152
Email   : suvarn[at]chem.iitb.ac.in

Synthesis of archaeal glycans :

Several N-linked glycoproteins have been identified in archaea and there is growing evidence that the N-glycan is involved in survival and functioning of archaea in extreme conditions. Chemical synthesis of the archaeal N-glycans represents a crucial step towards understanding the putative function of protein glycosylation in archaea.

The first total synthesis of the archaeal L-asparagine linked hexasaccharide from Methanothermus fervidus is reported using a highly convergent [3+3] glycosylation approach in high overall yields. The synthesis relies on efficient preparation of regioselectively protected thioglycoside building blocks for orthogonal glycosylations and late stage N-aspartylation.






















Publications :

  • Sanapala, S. R.; Kulkarni, S. S., Chem. Eur. J. 2014, 20, 3578-3583.